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Everyone's journey is different

For 1 out of 3 people with multiple myeloma, their multiple myeloma returns for the first time with no or minimal symptoms. If this is your experience, finding out you're relapsing may feel unexpected, but it’s not unusual, and there are treatment options that may allow you to keep an active lifestyle for longer.  

Choosing the right next therapy when your multiple myeloma returns is key to helping you maintain an active lifestyle.

Everyone with multiple myeloma will have different journeys, but there are some common experiences that are shared by most people whose multiple myeloma has returned. It doesn’t matter if it’s after initial treatment or following many treatments, it’s important to understand the events that can occur.

Multiple myeloma returns

For most people, multiple myeloma will eventually return. When multiple myeloma has come back and can be detected by advanced lab tests and imaging, it is known as a relapse.

Refractory disease

Multiple myeloma may have never responded or may stop responding to a particular treatment.

Treatment reselection

Together, you and your healthcare provider will determine what the next multiple myeloma treatment is that makes sense for you.

Treatment response

A response is when myeloma cells decrease after treatment, which shows up as improvement in the laboratory tests that measure the disease, such as blood tests showing a decrease of M protein.

Side effects

You may experience side effects with treatment. Ask your doctor how to best manage any side effects that occur. Make sure to report any serious side effects as soon as you can.


Take all medications as prescribed by your healthcare provider and stay on top of your appointments. The success of your treatment depends on it.


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