MULTIPLE MYELOMA CAN RETURN WITH OR WITHOUT SYMPTOMS
When multiple myeloma returns, the experience can be different for every person
Multiple myeloma will return for most people after a period of improvement following treatment, which is known as a relapse. Some people have symptoms when multiple myeloma comes back, while others may not. Some people only learn that a treatment change may be needed because of increasing levels of an abnormal antibody called M protein and lab results.
FOR PEOPLE WITH LIMITED OR NO SYMPTOMS
(Indolent relapse)
(Indolent relapse)
WHAT ARE THE SIGNS THAT MY MULTIPLE MYELOMA
HAS RETURNED?
Increasing M protein
- Increasing M protein levels (known as M spike and biochemical relapse)
Limited or no symptoms
- No obvious multiple myeloma symptoms (mild symptoms may not be noticeable)
- No organ problems
WHAT SHOULD I DO?
- Talk to your healthcare provider about your M proteins levels and how you're feeling—be sure to communicate any changes, even small ones
- Track M protein levels and stay on top of lab work using the lab test tracker
- Symptoms may be subtle at first, so be aware of any change in how you feel and let your healthcare provider know
FOR PEOPLE WITH SYMPTOMATIC RELAPSE
(Clinical relapse)
(Clinical relapse)
WHAT ARE THE SIGNS THAT MY MULTIPLE MYELOMA
HAS RETURNED?
Increasing M protein
- Increasing M protein levels (known as M spike)
Symptoms
- Obvious multiple myeloma symptoms such as fatigue, shortness of breath, or bone pain
- Symptoms may range from mild to severe and may change over time
- Organ problems may occur (such as kidney problems)
WHAT SHOULD I DO?
- Speak with your healthcare provider about all the symptoms you are experiencing, since it can be hard to know if symptoms are related to your multiple myeloma returning or another condition
- Use the conversation starter to help you think of a list of questions you may want to ask at your next visit
- Track M protein levels and stay on top of lab work using the lab test tracker
These suggestions are intended to provide information that may be helpful for people living with multiple myeloma. The suggestions provided are not intended to replace the advice of a patient's healthcare provider, and patients should always consult with their healthcare provider regarding their disease and treatment.
Tracking M protein is a way of monitoring your multiple myeloma
An increase of M protein in your blood is a sign that your multiple myeloma may have returned. The amount of M protein is measured using a multiple myeloma test, the M spike lab test. It is called an M spike when M protein is detected in your blood. Some people have myeloma cells that produce very little M protein, whereas others produce a lot of M protein, so it’s important to track your M protein levels individually over time.
Why multiple myeloma comes back
When multiple myeloma is controlled, it is known as remission. When you are in remission, there are no signs or symptoms of multiple myeloma, and in some cases, highly sensitive tests cannot detect any abnormal plasma cells.
Although treatment can reduce the number of myeloma cells in the body, there may be cells that remain or become resistant to treatment. Over time, these cells may start to multiply and can cause symptoms to come back. Advanced lab tests and imaging can detect signs of returning multiple myeloma, like rising M protein levels. Learn more about lab tests and imaging for multiple myeloma.
When multiple myeloma doesn’t initially respond or stops responding to a certain treatment, it is known as refractory multiple myeloma. This is also known as treatment resistance.
If your multiple myeloma has returned, it’s important to work with your doctor to determine the next treatment that’s right for you. How long remission lasts and the path your treatment journey takes will be different for every person, but you are not alone. There are resources and support groups that can help.
Multiple myeloma journey
Find out about what to expect after
multiple myeloma returns.